bs-60181C
[Life Science]
PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 401.26
Formula: C16 H14 Cl2 N2 O4 S
CAS Number: 17328-16-4
InChi Key: SHRCVZJKZJGIHQ-UHFFFAOYSA-N
InChi: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C16 H14 Cl2 N2 O4 S
CAS Number: 17328-16-4
InChi Key: SHRCVZJKZJGIHQ-UHFFFAOYSA-N
InChi: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1.5 μM. It has no activity against CARM1 and Set7/9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1.97 μM) and LNCaP prostate cancer cells (IC50 ~4.49 μM). It can attenuate androgen-induced gene expression in LNCaP cells.
Size: 10mg solid,5mg solid 10mg solid,5mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.