bs-60180C
[Life Science]
Fatostatin A --- Sterol Regulatory Binding Proteins (SREBPs) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 294.41
Formula: C18 H18 N2 S
CAS Number: 125256-00-0
InChi Key: ZROSUBKIGBSZCG-UHFFFAOYSA-N
InChi: InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H18 N2 S
CAS Number: 125256-00-0
InChi Key: ZROSUBKIGBSZCG-UHFFFAOYSA-N
InChi: InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50 ~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.
Size: 2mg solid ,10 mg solid 2mg solid ,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.