bs-60177C
[Life Science]
RVX-208 --- BET Bromodomain Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 370.4
Formula: C20 H22 N2 O5
CAS Number: 1044870-39-4
InChi Key: NETXMUIMUZJUTB-UHFFFAOYSA-N
InChi: InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)
Smiles: CC1C=C(C=C(C)C=1OCCO)C1NC(=O)C2C(=CC(=CC=2OC)OC)N=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C20 H22 N2 O5
CAS Number: 1044870-39-4
InChi Key: NETXMUIMUZJUTB-UHFFFAOYSA-N
InChi: InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)
Smiles: CC1C=C(C=C(C)C=1OCCO)C1NC(=O)C2C(=CC(=CC=2OC)OC)N=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
RVX-208, also known as Apabetalone, is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL-C, but the molecular target was not previously reported. RVX-208 may be a promising new approach to the treatment of atherosclerosis.
Size: 2 mg solid, 10 mg solid 2 mg solid, 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.