bs-60176C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 334.33

Formula: C19 H14 N2 O4

CAS Number: 48208-26-0

InChi Key: HPTXLHAHLXOAKV-INIZCTEOSA-N

InChi: InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1

Smiles: OC(=O)[C@H](CC1=CNC2=CC=CC=C21)N1C(=O)C2=CC=CC=C2C1=O

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

RG108 is a potent, selective and cell permeable inhibitor of DNA methyltransferase. Unlike 5-azaC, RG108 is not a nucleoside and therefore does not modify DNA. It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM. It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Treatment with RG108 results in the demethylation of genomic DNA and can reactivate epigenetically silenced tumor suppressor genes. It has been shown to improve the reprogramming efficiency of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem (iPS) cells. RG108 can potentially be used to maintain embryonic stem (ES) cells in an undifferentiated state as well as replace transcription factors in both mouse and human cell reprogramming.