bs-60156C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 362.4

Formula: C21 H19 F N4 O

CAS Number: 1357389-11-7

InChi Key: BLVQHYHDYFTPDV-VCABWLAWSA-N

InChi: InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+

Smiles: NC1=CC(F)=CC=C1NC(=O)/C=C/C1C=NN(CC=CC2C=CC=CC=2)C=1

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

RGFP966 is a potent and selective HDAC3 inhibitor. It has an IC50 of 0.08 μM for HDAC3 and displays no effective inhibition of any other HDAC at concentrations up to 15 μM. RGFP966 treatment on two cutaneous T cell lymphoma (CTCL) cell lines for 24 hours resulted in increased acetylation at H3K9/K14, H3K27, and H4K5, but not H3K56ac as revealed by western blot analysis. RGFP966 decreases cell growth of CTCL cell lines due to increased apoptosis that is associated with DNA damage and impaired S phase progression. Besides its use to study cancer biology, it also has specific neurological effects. Interestingly, RGFP966 treatment in vivo enhances long-term memory for object memory in mice. It facilitates extinction and prevents reinstatement of cocaine-conditioned place preference.