bs-60154C
[Life Science]
I-BET762 (GSK525762) --- BET Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 423.9
Formula: C22 H22 Cl N5 O2
CAS Number: 1260907-17-2
InChi Key: AAAQFGUYHFJNHI-SFHVURJKSA-N
InChi: InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
Smiles: CC1=NN=C2[C@H](CC(=O)NCC)N=C(C3C=C(C=CC=3N12)OC)C1C=CC(Cl)=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H22 Cl N5 O2
CAS Number: 1260907-17-2
InChi Key: AAAQFGUYHFJNHI-SFHVURJKSA-N
InChi: InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
Smiles: CC1=NN=C2[C@H](CC(=O)NCC)N=C(C3C=C(C=CC=3N12)OC)C1C=CC(Cl)=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
I-BET762 (GSK525762) is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain-containing proteins. In vivo studies using I-BET762 have demonstrated efficacy in a range of oncology and immunoinflammatory models. I-BET762 is currently in clinical development for oncology indication.
Size: 2mg solid ,10 mg solid, 10 mM in DMSO (0.47 2mg solid ,10 mg solid, 10 mM in DMSO (0.472 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.