bs-60152C
[Life Science]
AdipoRon --- Adiponectin Receptor/AdipoR agonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 428.52
Formula: C27 H28 N2 O3
CAS Number: 924416-43-3
InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N
InChi: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C27 H28 N2 O3
CAS Number: 924416-43-3
InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N
InChi: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AdipoRon is a novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR). AdipoRon binds to both AdipoR1 and AdipoR2 (EC50 for AdipoR1 ~1.8 µM and AdipoR2 ~3.1 µM). AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed with a high-fat diet, which was completely obliterated in AdipoR1 and AdipoR2 double-knockout mice. Moreover, AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon could serve as a very useful chemical probe for studies of obesity-related diseases such as type 2 diabetes by activating AdipoR1 and AdipoR2.
Size: 2 mg solid, 10 mg solid ,10 mM in DMSO (0.4 2 mg solid, 10 mg solid ,10 mM in DMSO (0.467 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.