bs-60145C
[Life Science]
LMK235 --- HDAC4 and HDAC5 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 294.35
Formula: C15 H22 N2 O4
CAS Number: 1418033-25-6
InChi Key: VRYZCEONIWEUAV-UHFFFAOYSA-N
InChi: InChI=1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
Smiles: CC1=CC(=CC(C)=C1)C(=O)NOCCCCCC(=O)NO
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H22 N2 O4
CAS Number: 1418033-25-6
InChi Key: VRYZCEONIWEUAV-UHFFFAOYSA-N
InChi: InChI=1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
Smiles: CC1=CC(=CC(C)=C1)C(=O)NOCCCCCC(=O)NO
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor (IC50 ~11.9 nM and 4.22 nM respectively). It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC50 for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 ~0.49 and 0.32 μM respectively).
Size: 10mg solid,2mg solid, 10 mM in DMSO (0.679 10mg solid,2mg solid, 10 mM in DMSO (0.679 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.