bs-60144C
[Life Science]
Bromosporine --- Pan-bromodomain Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 404.44
Formula: C17 H20 N6 O4 S
CAS Number: 1619994-69-2
InChi Key: UYBRROMMFMPJAN-UHFFFAOYSA-N
InChi: InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)
Smiles: CC1=NN=C2C(=CC(=NN12)C1C=CC(C)=C(C=1)NS(C)(=O)=O)NC(=O)OCC
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C17 H20 N6 O4 S
CAS Number: 1619994-69-2
InChi Key: UYBRROMMFMPJAN-UHFFFAOYSA-N
InChi: InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)
Smiles: CC1=NN=C2C(=CC(=NN12)C1C=CC(C)=C(C=1)NS(C)(=O)=O)NC(=O)OCC
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 (at 10 µM). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. It is a very useful chemical probe for bromodomain functional assays.
Size: 10mg solid, 10 mM in DMSO (0.494 mL), 2 mg i10mg solid, 10 mM in DMSO (0.494 mL), 2 mg in solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.