bs-60142C

DATASHEET

Formulation Powder

Storage: Powder: 4C for 1 year, -20C for 3 years

Product Information:

Molecular Weight: 250.34

Formula: C17 H18 N2

CAS Number: 49671-76-3

InChi Key: LQUNNCQSFFKSSK-UHFFFAOYSA-N

InChi: InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)

Smiles: CC(C)(C)C1C=CC(=CC=1)C1NC2C=CC=CC=2N=1

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: white to off-white solid powder

Shelf Life: 3.0 years

Description:

ZLN005 is a potent and selective small molecule PGC-1α transcriptional activator. It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation. Chronic oral administration of ZLN005 at 15 mg/kg per day to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. PGC-1α is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a useful chemical probe to study this target.