bs-60134C
[Life Science]
ML141 --- Cdc42 GTPase Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 407.49
Formula: C22 H21 N3 O3 S
CAS Number: 71203-35-5
InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N
InChi: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
Smiles: COC1C=CC(=CC=1)C1CC(=NN1C1C=CC(=CC=1)S(N)(=O)=O)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H21 N3 O3 S
CAS Number: 71203-35-5
InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N
InChi: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
Smiles: COC1C=CC(=CC=1)C1CC(=NN1C1C=CC(=CC=1)S(N)(=O)=O)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ML141 is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase. The EC50 for Cdc42 wild type and Cdc42Q61L mutant were 2.1 and 2.6 μM respectively. It has excellent selectivity for Cdc42 with no inhibition toward Rho and Rac in the same GTPase family, including Rac1, Rab2 and Rab7. In cellular assays ML141 inhibited Cdc42-related filopodia formation and cell migration.
Size: 10mg solid, 2mg solid , 10 mM in DMSO (0.49110mg solid, 2mg solid , 10 mM in DMSO (0.491 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.