bs-60131C
[Life Science]
5-Azacytidine --- DNA Methyltransferase Inhibitor
DATASHEET
Formulation Powder
Storage: Powder: 4C for 2 year, -20C for 3 years
Product Information:
Molecular Weight: 244.2
Formula: C8 H12 N4 O5
CAS Number: 320-67-2
InChi Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
InChi: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
Smiles: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Purity: 98.0
Solubility: H2O : 33.33 mg/mL (136.49 mM; Need ultrasonic); DMSO : ≥ 31 mg/mL (126.95 mM)
Appearance: White Solid Powder
Shelf Life: 3.0 years
Formula: C8 H12 N4 O5
CAS Number: 320-67-2
InChi Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
InChi: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
Smiles: NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Purity: 98.0
Solubility: H2O : 33.33 mg/mL (136.49 mM; Need ultrasonic); DMSO : ≥ 31 mg/mL (126.95 mM)
Appearance: White Solid Powder
Shelf Life: 3.0 years
Description:
5-Azacytidine is a classic DNA methyltransferase inhibitor. It incorporates into DNA forming covalent adducts with cellular DNMT, depleting enzyme activity. Azacitidine is widely used to demonstrate the correlation between loss of methylation in specific gene regions and activation of the associated genes. It can also improve the efficiency of reprogramming of stem cells, induce differentiation of mesenchymal stem cells into cardiomyocytes.
Size: 10mg solid, 5 mg solid10mg solid, 5 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.