bs-60129C
[Life Science]
C646 --- p300/CBP inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 445.42
Formula: C24 H19 N3 O6
CAS Number: 328968-36-1
InChi Key: HEKJYZZSCQBJGB-UNOMPAQXSA-N
InChi: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
Smiles: CC1=CC(=C(C=C1C)C1=CC=C(/C=C2\C(=O)N(N=C\2C)C2C=CC(=CC=2)C(O)=O)O1)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 30 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C24 H19 N3 O6
CAS Number: 328968-36-1
InChi Key: HEKJYZZSCQBJGB-UNOMPAQXSA-N
InChi: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
Smiles: CC1=CC(=C(C=C1C)C1=CC=C(/C=C2\C(=O)N(N=C\2C)C2C=CC(=CC=2)C(O)=O)O1)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 30 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
C646 is a potent, selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 ~400 nM. It competes with acetyl-CoA for the p300 Lys-CoA binding pocket selectively. It blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro. C646 has also been used to study the role of p300-mediated gene regulation in neuroscience. The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. C646 is a useful chemical probe to study p300/CBP HAT functions.
Size: 10mg solid, 2 mg solid, 10 mM in DMSO (0.44910mg solid, 2 mg solid, 10 mM in DMSO (0.449 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.