bs-60115C
[Life Science]
IWP-2 --- Porcupine (Wnt) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 466.6
Formula: C22 H18 N4 O2 S3
CAS Number: 686770-61-6
InChi Key: WRKPZSMRWPJJDH-UHFFFAOYSA-N
InChi: InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
Smiles: CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC=CC=3)=NC=2C=C1
Purity: 98.0
Solubility: DMSO up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H18 N4 O2 S3
CAS Number: 686770-61-6
InChi Key: WRKPZSMRWPJJDH-UHFFFAOYSA-N
InChi: InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
Smiles: CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC=CC=3)=NC=2C=C1
Purity: 98.0
Solubility: DMSO up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
IWP-2 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 27 nM in the L-Wnt-STF cellular assay. It prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. It blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP-2 is a useful chemical probe in both regenerative medicine and anticancer efforts.
Size: 10mg solid, 2mg solid ,10 mM DMSO (0.429 mL 10mg solid, 2mg solid ,10 mM DMSO (0.429 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.