bs-60108C
[Life Science]
EX-527 --- SIRT1 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 248.71
Formula: C13 H13 Cl N2 O
CAS Number: 49843-98-3
InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N
InChi: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
Smiles: NC(=O)C1CCCC2C3=CC(Cl)=CC=C3NC=21
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C13 H13 Cl N2 O
CAS Number: 49843-98-3
InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N
InChi: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
Smiles: NC(=O)C1CCCC2C3=CC(Cl)=CC=C3NC=21
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
EX-527 is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20-100 µM). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1.
Size: 2mg solid ,10 mg solid, 10 mM DMSO (0.804 m 2mg solid ,10 mg solid, 10 mM DMSO (0.804 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.