bs-60105C
[Life Science]
AGI-6780 --- Mutant IDH2 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 481.51
Formula: C21 H18 F3 N3 O3 S2
CAS Number: 1432660-47-3
InChi Key: CCAWRGNYALGPQH-UHFFFAOYSA-N
InChi: InChI=1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26,28)
Smiles: O=C(NC1C=CC=C(C=1)C(F)(F)F)NC1C=C(C=CC=1C1=CSC=C1)S(=O)(=O)NC1CC1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H18 F3 N3 O3 S2
CAS Number: 1432660-47-3
InChi Key: CCAWRGNYALGPQH-UHFFFAOYSA-N
InChi: InChI=1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26,28)
Smiles: O=C(NC1C=CC=C(C=1)C(F)(F)F)NC1C=C(C=CC=1C1=CSC=C1)S(=O)(=O)NC1CC1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.
Size: 2 mg solid,10 mg solid, 10 mM DMSO (0.415 m 2 mg solid,10 mg solid, 10 mM DMSO (0.415 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.