bs-60098C
[Life Science]
MALT1-MI-2 (MI-2) --- MALT1 inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 455.72
Formula: C19 H17 Cl3 N4 O3
CAS Number: 1047953-91-2
InChi Key: TWJGQZBSEMDPQP-UHFFFAOYSA-N
InChi: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
Smiles: COCCOC1N=C(C2=CC(Cl)=C(Cl)C=C2)N(N=1)C1C=CC(=CC=1)NC(=O)CCl
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C19 H17 Cl3 N4 O3
CAS Number: 1047953-91-2
InChi Key: TWJGQZBSEMDPQP-UHFFFAOYSA-N
InChi: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
Smiles: COCCOC1N=C(C2=CC(Cl)=C(Cl)C=C2)N(N=1)C1C=CC(=CC=1)NC(=O)CCl
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
MALT1-MI-2 (MI-2) is a highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function. MI-2 concentrated within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates with EC50 < 1 µM (HBL-1 ~200 nM; TMD8 ~500 nM). This was accompanied by NF-κB pathway suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MI-2 was nontoxic to mice, and displayed selective activity against ABC-DLBCL cell lines in vitro and xenotransplanted ABC-DLBCL tumors in vivo. It was also effective against primary human non-germinal center B cell-like DLBCLs ex vivo.
Size: 25mg solid, 2mg solid ,10 mM DMSO (0.439 mL 25mg solid, 2mg solid ,10 mM DMSO (0.439 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.