bs-60095C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 569.58

Formula: C28 H30 F3 N7 O3

CAS Number: 1421227-52-2

InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N

InChi: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39)

Smiles: CN1CCN(CC2C=CC(=CC=2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

WS3 is a highly potent and selective small molecule that promotes pancreatic β cell and RPE cells expansion, identified by a high-throughput, cell-based screening. It can induce proliferation of mouse R7T1 β cells with an EC50 ~0.074 µM, and expansion of primary rat and human β cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. Furthermore, chemically expanded RPE cells preserve vision when transplanted into dystrophic Royal College of Surgeons (RCS) rats, a well-established model of retinal degeneration.