bs-60081C
[Life Science]
SAG --- Hedgehog Agonist
DATASHEET
Formulation Powder
Storage: Powder: 4C for 1 year.
Product Information:
Molecular Weight: 490.06
Formula: C28 H28 Cl N3 O S
CAS Number: 364590-63-6
InChi Key: VFSUUTYAEQOIMW-YHBQERECSA-N
InChi: InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
Smiles: CN[C@@H]1CC[C@H](CC1)N(CC1C=CC=C(C=1)C1C=CN=CC=1)C(=O)C1SC2=CC=CC=C2C=1Cl
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Powder Solid
Shelf Life: 1.0 years
Formula: C28 H28 Cl N3 O S
CAS Number: 364590-63-6
InChi Key: VFSUUTYAEQOIMW-YHBQERECSA-N
InChi: InChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
Smiles: CN[C@@H]1CC[C@H](CC1)N(CC1C=CC=C(C=1)C1C=CN=CC=1)C(=O)C1SC2=CC=CC=C2C=1Cl
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Powder Solid
Shelf Life: 1.0 years
Description:
SAG is a potent, selective, and cell-permeable small-molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo. It was reported that SAG acts as an activator at low concentrations and as an inhibitor at high concentrations (>1 µM). In recent studies, SAG was shown to prevent glucocorticoid-induced neonatal cerebellar injury, and trigger rapid metabolic rewiring via AMPK.
Size: 10mg solid, 2 mg solid,10 mM DMSO (0.408 mL 10mg solid, 2 mg solid,10 mM DMSO (0.408 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.