bs-60069C
[Life Science]
BAM7 --- BAX Activator
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 405.47
Formula: C21 H19 N5 O2 S
CAS Number: 331244-89-4
InChi Key: KOCVKGYKBLJEPK-LYBHJNIJSA-N
InChi: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
Smiles: CC1=NN(C(=O)C1=NNC1=CC=CC=C1OCC)C1=NC(=CS1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H19 N5 O2 S
CAS Number: 331244-89-4
InChi Key: KOCVKGYKBLJEPK-LYBHJNIJSA-N
InChi: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
Smiles: CC1=NN(C(=O)C1=NNC1=CC=CC=C1OCC)C1=NC(=CS1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
BAM7 is the first potent and selective small molecule activator of BAX, which is a pro-apoptotic BCL-2 family member. It binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation, and does not interact with the BH3-binding pocket of antiapoptotic proteins or proapoptotic BAK. It induces cell death in a BAX-dependent fashion. It can also induce the biochemical and morphologic features of BAX-mediated apoptosis in Bak-/- MEFs. BAM7 is selective for the BH3-binding groove at the N-terminal face of BAX and thus may serve as a powerful chemical tool for dissecting the physiologic consequences of direct BAX activation in a variety of homeostatic and pathologic conditions.
Size: 2 mg solid, 10mg solid, 10 mM in DMSO (0.4942 mg solid, 10mg solid, 10 mM in DMSO (0.494 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.