DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 262.35
Formula: C15 H22 N2 O2
CAS Number: 347174-05-4
InChi Key: UJHBVMHOBZBWMX-UHFFFAOYSA-N
InChi: InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
Smiles: CCOC(=O)C1=CC(N)=C(C=C1)NC1CCCCC1
Purity: 98.0
Solubility: DMSO up to 100mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin-induced ferroptosis in HT-1080 cells. Ferroptosis is a unique iron-dependent form of nonapoptotic cell death triggered by the oncogenic RAS-selective lethal small molecule erastin. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. Ferrostatin-1 was shown to inhibit ferroptosis in cancer cells, and also glutamate-induced cell death in organotypic rat brain slices. Studies revealed that erastin blocks cystine uptake via inhibition of the cystine/glutamate antiporter, resulting in a defect in the cell’s antioxidative defenses and ultimately leading to an iron-dependent, oxidative cell death (i.e., ferroptosis). Ferrostatin-1 was characterized to prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 serves as a very useful tool to dissect ferroptosis in cancer and many other cell types, and may provide new opportunities to protect tissues and organs from damages resulted from ferroptosis under diseases (such as neurodegeneration).
Size:
10mg solid, 2mg solid , 10 mM in DMSO (0.76310mg solid, 2mg solid , 10 mM in DMSO (0.763 mL)
Applications:
Life Science()
For research use only. Not intended for diagnostic or therapeutic use.