bs-60039C
[Life Science]
BAF312 --- S1P1/5 Selective Agonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 516.6
Formula: C29 H35 F3 N2 O3
CAS Number: 800379-64-0
InChi Key: KIHYPELVXPAIDH-HNSNBQBZSA-N
InChi: InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
Smiles: C/C(=N\OCC1=CC(=C(C=C1)C1CCCCC1)C(F)(F)F)/C1C=CC(CN2CC(C2)C(O)=O)=C(CC)C=1
Purity: 98.0
Solubility: DMSO up to 20mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C29 H35 F3 N2 O3
CAS Number: 800379-64-0
InChi Key: KIHYPELVXPAIDH-HNSNBQBZSA-N
InChi: InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
Smiles: C/C(=N\OCC1=CC(=C(C=C1)C1CCCCC1)C(F)(F)F)/C1C=CC(CN2CC(C2)C(O)=O)=C(CC)C=1
Purity: 98.0
Solubility: DMSO up to 20mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 (EC50 ~0.39 nM) and S1P5 (EC50 ~0.98 nM). As S1P1 plays a central role in lymphocyte egress from lymph nodes and is a validated drug target in immune-mediated diseases, BAF312 is currently in clinical trials to treat multiple sclerosis.
Size: 10mg solid, 2 mg solid, 10 mM in DMSO (0.38810mg solid, 2 mg solid, 10 mM in DMSO (0.388 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.