bs-60034C
[Life Science]
GDC-0449 (Vismodegib) --- Hedgehog Antagonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 421.3
Formula: C19 H14 Cl2 N2 O3 S
CAS Number: 879085-55-9
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
Smiles: CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC(C2C=CC=CN=2)=C(Cl)C=C1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C19 H14 Cl2 N2 O3 S
CAS Number: 879085-55-9
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
Smiles: CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC(C2C=CC=CN=2)=C(Cl)C=C1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Vismodegib (GDC-0449) is a potent and specific hedgehog pathway inhibitor with an IC50 of 3 nM. It has been approved by FDA to treat BCC, and also in multiple clinical trials to treat advanced solid tumors. It blocks the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. It prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 also exhibited efficacy in medulloblastoma animal models and primary pancreatic cancer xenograft models. It was shown to inhibit cell growth in cisplatin-resistant lung cancer cells.
Size: 2 mg solid, 10 mg solid , 10 mM in DMSO (0.42 mg solid, 10 mg solid , 10 mM in DMSO (0.475 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.