bs-60033C
[Life Science]
CP-690550 --- JAK Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 312.37
Formula: C16 H20 N6 O
CAS Number: 477600-75-2
InChi Key: UJLAWZDWDVHWOW-YPMHNXCESA-N
InChi: InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
Smiles: CN([C@H]1CN(CC[C@H]1C)C(=O)CC#N)C1=NC=NC2NC=CC=21
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C16 H20 N6 O
CAS Number: 477600-75-2
InChi Key: UJLAWZDWDVHWOW-YPMHNXCESA-N
InChi: InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
Smiles: CN([C@H]1CN(CC[C@H]1C)C(=O)CC#N)C1=NC=NC2NC=CC=21
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
CP-690550 is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3.2 nM), JAK2 (IC50 ~4.1 nM), and JAK3 (IC50 ~1.6 nM). In cellular assays CP-690550 showed potent effects in the IL-2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM, mediated via JAK2), but has relatively minimal effects on general cell growth (>10 µM activity in the HFF assay).
Size: 2 mg solid,10 mM in DMSO (0.641 mL), 25 mg 2 mg solid,10 mM in DMSO (0.641 mL), 25 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.