bs-60032C
[Life Science]
BMS-708163 (Avagacestat) --- γ-Secretase Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 520.88
Formula: C20 H17 Cl F4 N4 O4 S
CAS Number: 1146699-66-2
InChi Key: XEAOPVUAMONVLA-QGZVFWFLSA-N
InChi: InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
Smiles: NC(=O)[C@@H](CCC(F)(F)F)N(CC1C=CC(=CC=1F)C1=NOC=N1)S(=O)(=O)C1C=CC(Cl)=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C20 H17 Cl F4 N4 O4 S
CAS Number: 1146699-66-2
InChi Key: XEAOPVUAMONVLA-QGZVFWFLSA-N
InChi: InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
Smiles: NC(=O)[C@@H](CCC(F)(F)F)N(CC1C=CC(=CC=1F)C1=NOC=N1)S(=O)(=O)C1C=CC(Cl)=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
BMS-708163 (Avagacestat) is a potent, selective and orally bioavailable γ-secretase inhibitor with an IC50 of 0.3 nM for APP cleavage. It is 190-fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS-708163 decreased CSF Aβ40 and Aβ42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg.
Size: 2 mg solid,10 mg solid, 10 mM in DMSO (0.38 2 mg solid,10 mg solid, 10 mM in DMSO (0.385 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.