bs-60027C
[Life Science]
Kartogenin (KGN) --- Chondrogenesis Modulator
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 317.34
Formula: C20 H15 N O3
CAS Number: 4727-31-5
InChi Key: SLUINPGXGFUMLL-UHFFFAOYSA-N
InChi: InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
Smiles: OC(=O)C1C=CC=CC=1C(=O)NC1C=CC(=CC=1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C20 H15 N O3
CAS Number: 4727-31-5
InChi Key: SLUINPGXGFUMLL-UHFFFAOYSA-N
InChi: InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
Smiles: OC(=O)C1C=CC=CC=1C(=O)NC1C=CC(=CC=1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Kartogenin (KGN) is a potent small molecule that can promote chondrocyte differentiation of human mesenchymal stem cells/MSCs (EC50 = 100 nM). It was identified by an imaging-based high throughput screening in human MSCs. KGN also shows chondro-protective effects in vitro, and is efficacious in collagenase and surgery induced OA models in mice. MOA studies suggested that KGN binds to filamin A, disrupts its interaction with the transcription factor CBFβ, and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. Kartogenin serves as a very useful tool to study and promote chondrogenesis, and may provide a new strategy of cell-based therapy for treating osteoarthritis.
Size: 10mg solid, 2mg solid , 10 mM in DMSO (0.63110mg solid, 2mg solid , 10 mM in DMSO (0.631 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.