bs-60022C
[Life Science]
Cyclopamine --- Hedgehog Antagonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 411.62
Formula: C27 H41 N O2
CAS Number: 4449-51-8
InChi Key: QASFUMOKHFSJGL-LAFRSMQTSA-N
InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
Smiles: C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC2[C@H]1CC[C@]1(O[C@@H]3C[C@H](C)CN[C@H]3[C@H]1C)C=2C
Purity: 98.0
Solubility: DMSO up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C27 H41 N O2
CAS Number: 4449-51-8
InChi Key: QASFUMOKHFSJGL-LAFRSMQTSA-N
InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
Smiles: C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC2[C@H]1CC[C@]1(O[C@@H]3C[C@H](C)CN[C@H]3[C@H]1C)C=2C
Purity: 98.0
Solubility: DMSO up to 20 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Cyclopamine is a potent and selective inhibitor of the hedgehog signaling with an IC50 ~46 nM, acting as an antagonist of Smoothened. It is a natural product isolated from the corn lily (Veratrum californicum). As the hedgehog signaling pathway plays very important roles in embryogenesis and cancer progression, Cyclopamine has been used in stem cell differentiation, such as pancreatic cell differentiation from ESC/iPSC, or treating Hh pathway dependent cancer in vitro and in vivo.
Size: 2 mg solid, 10 mg solid ,10 mM in DMSO (0.4 2 mg solid, 10 mg solid ,10 mM in DMSO (0.487 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.