bs-60020C
[Life Science]
A769662 --- AMPK Activator
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 360.39
Formula: C20 H12 N2 O3 S
CAS Number: 844499-71-4
InChi Key: CTESJDQKVOEUOY-UHFFFAOYSA-N
InChi: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
Smiles: N#CC1C(=O)NC2SC=C(C=2C=1O)C1C=CC(=CC=1)C1C=CC=CC=1O
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C20 H12 N2 O3 S
CAS Number: 844499-71-4
InChi Key: CTESJDQKVOEUOY-UHFFFAOYSA-N
InChi: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
Smiles: N#CC1C(=O)NC2SC=C(C=2C=1O)C1C=CC(=CC=1)C1C=CC=CC=1O
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
A769662 is a potent and selective small-molecule activator of AMP-activated protein kinase (AMPK). It induces allosteric activation of AMPK and inhibition of dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. The activation of AMPK inhibits mTOR signaling, which is a positive effector of cell growth and survival. A769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM. It can also stimulate Na+, K+-ATPase activity in skeletal muscle cells.
Size: 5 mg solid,50mg solid, 10 mM in DMSO (1.389 5 mg solid,50mg solid, 10 mM in DMSO (1.389 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.