bs-60019C
[Life Science]
P22077 --- USP7 inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 315.32
Formula: C12 H7 F2 N O3 S2
CAS Number: 1247819-59-5
InChi Key: RMAMGGNACJHXHO-UHFFFAOYSA-N
InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
Smiles: CC(=O)C1=CC(=C(S1)SC1C=CC(F)=CC=1F)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 100mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C12 H7 F2 N O3 S2
CAS Number: 1247819-59-5
InChi Key: RMAMGGNACJHXHO-UHFFFAOYSA-N
InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
Smiles: CC(=O)C1=CC(=C(S1)SC1C=CC(F)=CC=1F)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 100mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
P22077 is a potent and selective USP7 inhibitor that was recently identified using an Ub-CHOP reporter assay. It was shown to have potent and selective inhibitory activity against USP7 and closely related USP47 at ~5 µM, but not other DUBs (at ~15-45 µM). USP7, also known as HAUSP, plays an important role in cancer progression as it affects the stability of p53. The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53, and USP7 exerts both p53-dependent and p53-independent effects on controlling cell proliferation and apoptosis.
Size: 2 mg solid, 10 mg solid ,10 mM in DMSO (0.6 2 mg solid, 10 mg solid ,10 mM in DMSO (0.635 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.