bs-60018C
[Life Science]
PD0325901 --- MEK Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 482.19
Formula: C16 H14 F3 I N2 O4
CAS Number: 391210-10-9
InChi Key: SUDAHWBOROXANE-SECBINFHSA-N
InChi: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
Smiles: OC[C@@H](O)CONC(=O)C1C=CC(F)=C(F)C=1NC1C=CC(I)=CC=1F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C16 H14 F3 I N2 O4
CAS Number: 391210-10-9
InChi Key: SUDAHWBOROXANE-SECBINFHSA-N
InChi: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
Smiles: OC[C@@H](O)CONC(=O)C1C=CC(F)=C(F)C=1NC1C=CC(I)=CC=1F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PD0325901 is a highly potent and selective inhibitor of MEK with an IC50 of 0.33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e.g., CI-1040). It can potently inhibit the phosphorylation and activation of MAPK/ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self-renewal and iPSC generation.
Size: 2 mg solid,25mg solid, 10 mM in DMSO (0.415 2 mg solid,25mg solid, 10 mM in DMSO (0.415 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.