bs-60012C
[Life Science]
J147 --- Neuroprotective Small Molecule
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 350.33
Formula: C18 H17 F3 N2 O2
CAS Number: 1146963-51-0
InChi Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N
InChi: InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
Smiles: COC1C=C(/C=N/N(C(=O)C(F)(F)F)C2C=CC(C)=CC=2C)C=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H17 F3 N2 O2
CAS Number: 1146963-51-0
InChi Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N
InChi: InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
Smiles: COC1C=C(/C=N/N(C(=O)C(F)(F)F)C2C=CC(C)=CC=2C)C=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
J147 is a potent and orally active neurotrophic molecule discovered based upon efficacy in multiple cellular models of age-associated pathologies rather than exclusively amyloid metabolism. J147 is broadly neuroprotective, and active in six different assays that represent distinct neurotoxicity pathways related to aging and neurodegenerative diseases, with EC50 between 10 and 200 nM. It can also improve memory in normal rodents, and prevent the loss of synaptic proteins and cognitive decline in a transgenic AD mouse model.
Size: 10mg solid,2mg solid, 10 mM in DMSO (0.571 10mg solid,2mg solid, 10 mM in DMSO (0.571 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.