bs-60007C
[Life Science]
RO4929097 --- γ-Secretase Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 469.4
Formula: C22 H20 F5 N3 O3
CAS Number: 847925-91-1
InChi Key: OJPLJFIFUQPSJR-INIZCTEOSA-N
InChi: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
Smiles: CC(C)(C(=O)N[C@H]1C2C=CC=CC=2C2C=CC=CC=2NC1=O)C(=O)NCC(F)(F)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H20 F5 N3 O3
CAS Number: 847925-91-1
InChi Key: OJPLJFIFUQPSJR-INIZCTEOSA-N
InChi: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
Smiles: CC(C)(C(=O)N[C@H]1C2C=CC=CC=2C2C=CC=CC=2NC1=O)C(=O)NCC(F)(F)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
RO4929097 is a highly potent and selective γ-secretase inhibitor with an IC50 ~4 nM. It can cause a dramatic reduction of the intracellular Notch level and lead to significantly decreased expression of the Notch transcriptional target genes, such as Hes1. It exhibits potent inhibitory activity of Notch signaling in tumor cells. Currently RO4929097 is in multiple phase I/II clinical trials to treat cancer.
Size: 10mg solid, 2 mg solid, 10 mM in DMSO (0.42610mg solid, 2 mg solid, 10 mM in DMSO (0.426 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.