bs-60004C
[Life Science]
Hh-Ag1.5 --- Hedgehog Agonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 526.04
Formula: C28 H26 Cl F2 N3 O S
CAS Number: 612542-14-0
InChi Key: RXZDWPYJFCAZCW-MEMLXQNLSA-N
InChi: InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4,9-15,20-21,32H,5-8,16H2,1H3/t20-,21-
Smiles: CN[C@@H]1CC[C@H](CC1)N(CC1C=C(C=CC=1)C1C=CN=CC=1)C(=O)C1SC2=C(C=1Cl)C(F)=CC=C2F
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C28 H26 Cl F2 N3 O S
CAS Number: 612542-14-0
InChi Key: RXZDWPYJFCAZCW-MEMLXQNLSA-N
InChi: InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4,9-15,20-21,32H,5-8,16H2,1H3/t20-,21-
Smiles: CN[C@@H]1CC[C@H](CC1)N(CC1C=C(C=CC=1)C1C=CN=CC=1)C(=O)C1SC2=C(C=1Cl)C(F)=CC=C2F
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Studies showed that it has more potent activity than the recombinant Hh protein in activating Smo and hedgehog pathway.
Size: 2 mg solid, 10 mM in DMSO (0.380 mL), 10 mg 2 mg solid, 10 mM in DMSO (0.380 mL), 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.