bs-60001C
[Life Science]
StemRegenin1 (SR1) --- HSC Expansion Molecule
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 429.54
Formula: C24 H23 N5 O S
CAS Number: 1227633-49-9
InChi Key: BGFHMYJZJZLMHW-UHFFFAOYSA-N
InChi: InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
Smiles: CC(C)N1C=NC2=C(NCCC3C=CC(O)=CC=3)N=C(N=C12)C1=CSC2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C24 H23 N5 O S
CAS Number: 1227633-49-9
InChi Key: BGFHMYJZJZLMHW-UHFFFAOYSA-N
InChi: InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
Smiles: CC(C)N1C=NC2=C(NCCC3C=CC(O)=CC=3)N=C(N=C12)C1=CSC2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
StemRegenin1 (SR1) is a selective, cell-permeable antagonist of aryl hydrocarbon receptor. It can promote robust expansion and self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs, EC50 ~120 nM). SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice. Culture of HSCs with 1 µM SR1 for 21 days led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Currently Novartis is conducting clinical trials, “LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies”, related to this research.
Size: 2 mg solid, 10mg solid, 10 mM in DMSO (0.4662 mg solid, 10mg solid, 10 mM in DMSO (0.466 mL)
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.