bs-5791R-Cy3 [Conjugated Primary Antibody]
Integrin Alpha V + Beta 6 Antibody, Cy3 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Integrin Alpha V + Beta 6

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3685 3694

Source: KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.

Conjugation: Cy3

Excitation/ Emission: 512,550nm/570,615nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 18/95/113


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Gao, Duo, et al."A near-infrared phthalocyanine dye-labeled agent for integrin avb6-targeted theranostics of pancreatic cancer." Biomaterials 53 (2015):229-238.Read more>>
  • Bian, Qin, et al. "Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis." Bone Research 5 (2017): 17008.Read more>>
  • Li, Haixia, et al. "Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and-9 and αvβ6 integrin." International Journal of Oncology 42.5 (2013): 1674-1681.Read more>>
  • McLaughlan, James, et al. "Increasing the sonoporation efficiency of targeted polydisperse microbubble populations using chirp excitation." IEEE transactions on ultrasonics, ferroelectrics, and frequency control 60.12 (2013): 2511-2520.Read more>>
  • Cargnoni, Anna, et al. "Effect of human amniotic epithelial cells on pro‐fibrogenic resident hepatic cells in a rat model of liver fibrosis." Journal of Cellular and Molecular Medicine.Read more>>
  • Liu Chung-Te. et al. Parathyroid hormone induces transition of myofibroblasts in arteriovenous fistula and increases maturation failure. Endocrinology. 2021 FebRead more>>
  • Anca D. Petrescu. et al. Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep-Uk. 2020 Sep;10(1):1-19Read more>>
  • Gehua Zhen. et al. Mechanical stress determines the configuration of TGF activation in articular cartilage. Nat Commun. 2021 Mar;12(1):1-16Read more>>
  • Dengfeng Li. et al. Integrin v6-targeted MR molecular imaging of breast cancer in a xenograft mouse model. Cancer Imaging. 2021 Dec;21(1):1-11Read more>>
  • Xiao Wang. et al. Inhibition of Integrin _v_6 Activation of TGF-_ Attenuates Tendinopathy. 2022 Feb 15Read more>>
  • Elena Andreucci. et al. Nintedanib-αVβ6 Integrin Ligand Conjugates Reduce TGFβ-Induced EMT in Human Non-Small Cell Lung Cancer. INT J MOL SCI. 2023 Jan;24(2):1475Read more>>
  • Liangtao Ye. et al. The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4-/- Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology. AGING DIS. 2024 Feb 1; 15(1): 338C356Read more>>
  • Einav Hubel. et al. Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and Fibrosis during Cholestatic Injury. AM J PATHOL. 2024 MaRead more>>
VALIDATION IMAGES