bs-5610R

DATASHEET

Host: Rabbit

Target Protein: TSC2 Ser1798

Specificity: Phosphorylation site corresponds to Ser1805 in mouse and Ser1800 in rat.

Modification Site: Ser1798

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7249

Swiss Prot: P49815

Source: KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1798

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 200

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human
Mouse
Dog
Pig
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.