bs-5447R-BF750 [Conjugated Primary Antibody]
IGF1R (Tyr980) Polyclonal Antibody, AbBy Fluor® 750 Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: IGF1R Tyr980

Modification Site: Tyr980

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3480

Swiss Prot: P08069

Source: KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr980

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Conjugation: AbBy Fluor® 750

Excitation/ Emission: 749nm/775nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 150


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tang, Hexiao, et al. "Estrogen and insulin?\like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice."International Journal of Cancer (2013)..Read more>>
  • Lee, Yongik, et al. "Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells." Molecular Carcinogenesis (2015).Read more>>
  • Tang et al. Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice. (2013) Int.J.Cancer. 133:2473-82Read more>>
  • Zhiyuan Wang. et al. IGF1c mimetic peptide-based supramolecular hydrogel microspheres synergize with neural stem cells to promote functional recovery from spinal cord injury. NANO TODAY. 2023 Aug;51:101894Read more>>
VALIDATION IMAGES