DATASHEET
Host:
Rabbit
Target Protein:
SLC40A1
Immunogen Range:
331-430/571
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
30061
Swiss Prot:
Q9NP59
Source:
KLH conjugated synthetic peptide derived from human SLC40A1/FPN1
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Background:
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
PRODUCT SPECIFIC PUBLICATIONS
- Rychtarcikova, Zuzana, et al. "Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism." Oncotarget (2016).Read more>>
- Zhang, L. Y., et al. "Effect of iron source on iron absorption and gene expression of iron transporters in the ligated duodenal loops of broilers." Journal of Animal Science (2017).Read more>>
- Calatrava-Ferreras et al. Liver Growth Factor (LGF) Upregulates Frataxin Protein Expression and Reduces Oxidative Stress in Friedreich's Ataxia Transgenic Mice. (2016) Int.J.Mol.Sci. 17 Read more>>
- Wang,et al.Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1/2 signaling pathway.(2018) Experimental Cell Research. 364:168-174.Read more>>
- Zixuan Liu. et al. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. Chemosphere. 2021 Feb;264:128413Read more>>
- Zixuan Liu. et al. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicol Appl Pharm. 2020 Nov;407:115241Read more>>
- Qingxin Song. et al. Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells. Yonsei Med J. 2021 Sep 1; 62(9): 843C849Read more>>
- Ma, Sai. et al. Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction. N-S ARCH PHARMACOL. 2022 Apr;:1-18Read more>>
- Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555Read more>>
- Xu Zhu. et al. Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway. BIOMED PHARMACOTHER. 2023 Nov;167:115567Read more>>
- Shan Pang. et al. Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway. PESTIC BIOCHEM PHYS. 2024 Mar;:105885Read more>>
- Jing Zhao. et al. Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis. REDOX BIOL. 2024 Jun;72:10316Read more>>
- Yang Chen. et al. Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway. EUR J MED RES. 2024; 29: 387Read more>>
VALIDATION IMAGES
Lane 1: Human A673 Cells; 30ug loaded into lane; Probed with SLC40A1 Polyclonal Antibody, Unconjugated (bs-4906R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Lane 1: K562 cell lysates; Lane 2: HepG2 cell lysates probed with SLC40A1 Polyclonal Antibody, Unconjugated (bs-4906R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Lane 1: Human Hepg2 cell lysates; Lane 2: Human K562 cell lysates; Lane 3: Human Molt-4 cell lysates; Lane 4: Human Jurkat cell lysates probed with SLC40A1 Polyclonal Antibody, Unconjugated (bs-4906R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.