bs-4727R-PE [Conjugated Primary Antibody]
MRC1 Polyclonal Antibody, PE Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: MRC1

Immunogen Range: 201-300/1456


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4360

Swiss Prot: P22897

Source: KLH conjugated synthetic peptide derived from human MRC1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 160


Cross Reactive Species: Human
Mouse
Rat
Dog

Predicted Cross Reactive Species: Cow
Sheep
Pig
Horse
Chicken
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Karmouty-Quintana, Harry, et al. "Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension." The FASEB Journal (2014): fj-14.Read more>>
  • Das, Anusuya, et al. "Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras." Biomaterials (2015).Read more>>
  • Azad, Abul K., et al. "γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)." The Journal of Immunology (2015): 1402005.Read more>>
  • Locatelli, Luigi, et al. "Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis."Hepatology (2016).Read more>>
  • Struecker, B., et al. "Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs." European Surgical Research 56.1-2 (2015): 61-75.Read more>>
  • Zhu, Dan, et al. "M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-β-Treated Rats Through Regulation of Microglial Polarization." Journal of Alzheimers Disease: 1-13.Read more>>
  • Blomgran, Parmis, et al. "A possible link between loading, inflammation and healing: Immune cell populations during tendon healing in the rat." Scientific Reports 6 (2016): 29824.Read more>>
  • Nakai et al. IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice. (2017) Sci.Rep. 7:12473Read more>>
  • Nishikawa,et al.Highly Dispersible and Bioavailable Curcumin but not Native Curcumin Induces Brown-Like Adipocyte Formation in Mice.(2018) Molecular Nutrition & Food Research. 62:.Read more>>
  • White,et al.GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.(2018) Endocrine-Related Cancer. 25:453-469.Read more>>
  • Shi F et al. Heat injured stromal cells-derived exosomal EGFR enhances prostatic wound healing afterthulium laser resection through EMT and NF-κB signaling. Prostate. 2019 May 24. Read more>>
  • Ma R et al. Exploring the interactions between engineered nanomaterials and immune cells at 3D Nano-bio interfaces to discover potent Nano-adjuvants. Nanomedicine. 2019 Jun 18;21:102037. Read more>>
  • Xie W et al. Dose Dependent Modulation of Bioactive Glasses Particles on Macrophage and Diabetic Wound Healing. Journal of Materials Chemistry B. 2018.Read more>>
  • Žaloudíková M et al. The effect of exposure to hypoxia on superoxide formation by alveolar macrophages is indirect. Life Sci. 2019 Sep 10;236:116864.Read more>>
  • Nishikawa S et al. Co-Administration of Curcumin and Artepillin C Induces Development of Brown-Like Adipocytes in Association with Local Norepinephrine Production by Alternatively Activated Macrophages in Mice. J Nutr Sci Vitaminol (Tokyo). 2019;65(4):328-334. Read more>>
  • Shao N et al. A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy. Macromol Biosci. 2019 Nov 10:e1900255. Read more>>
  • Jiang L et al. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. Eur J Pharm Biopharm. 2020 Jan;146:101-110.Read more>>
  • Zhan Q et al. Structural characterization and immunomodulatory activity of a novel acid polysaccharide isolated from the pulp of Rosa laevigata Michx fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.Read more>>
  • Liu J et al. Polychlorinated biphenyl quinone promotes macrophage polarization to CD163+ cells through Nrf2 signaling pathway. Environmental Pollution,2019, 113587. Read more>>
  • Shao N et al. A Multi‐Functional Silicon Nanoparticle Designed for Enhanced Osteoblast Calcification and Related Combination Therapy. Macromol Biosci. 2019 Nov 10:e1900255. Read more>>
  • Liu S et al. Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing. Adv Healthc Mater. 2020 Apr 27:e2000198.Read more>>
  • Tong?L et al. ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics. 2020 May 1;10(13):5943-5956.Read more>>
  • Gitto SB et al. Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. Cell Commun Signal. 2020 Jun 17;18(1):95.Read more>>
  • Yitian Du. et al. Engineered Microglia Potentiate the Action of Drugs against Glioma Through Extracellular Vesicles and Tunneling Nanotubes. 2021 Feb 28Read more>>
  • Hao Liu. et al. A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription. Vet Immunol Immunop. 2021 Apr;234:110202Read more>>
  • Sha Liu. et al. Dual Cross-linked HHA Hydrogel Supplies and Regulates M2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing. Biomacromolecules. 2020;21(9):3795C3806Read more>>
  • Jiyuan Piao. et al. Substance P blocks -aminopropionitrile-induced aortic injury through modulation of M2 monocyte-skewed monocytopoiesis. Transl Res. 2021 Feb;228:76Read more>>
  • Xiaowei Li. et al. Pristane promotes anaerobic glycolysis to facilitate proinflammatory activation of macrophages and development of arthritis. Exp Cell Res. 2021 Jan;398:112404Read more>>
  • Simon Harper. et al. Portal venous repopulation of decellularised rat liver scaffolds with syngeneic bone marrow stem cells. J Tissue Eng Regen M. 2020 Oct;14(10):1502-1512Read more>>
  • Kohei Kamada. et al. Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells. J Clin Med. 2021 Jan;10(19):4309Read more>>
  • Meng Lin. et al. CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy. Nano Today. 2022 Feb;42:101359Read more>>
  • Nguyen, Thao K. T.. et al. Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice. Arch Immunol Ther Ex. 2022 Dec;70(1):1-13Read more>>
  • Jing Wang. et al. Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9-NF-_B signaling pathway in severe acute pancreatitis. J HEPATO-BIL-PAN SCI. 2022 Jun 23Read more>>
  • Xuan Li. et al. ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation. BIOMATERIALS. 2022 Aug;287:121683Read more>>
  • Linghao Xiao. et al. Osteogenic capacity of octacalcium phosphate involving macrophage polarization. J BIOMED MATER RES A. 2022 DecRead more>>
  • Xin Li. et al. Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS NEUROSCI THER. 2023 ApRead more>>
  • Kagioka Takumi. et al. Lithium carbonate accelerates the healing of apical periodontitis. SCI REP-UK. 2023 May;13(1):1-12Read more>>
  • Wu Guanghao. et al. Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis. NANO RES. 2023 Sep;:1-1Read more>>
  • Yanan Jiang. et al. A MetalCOrganic Framework-Incorporated Hydrogel for Delivery of Immunomodulatory Neobavaisoflavone to Promote Cartilage Regeneration in Osteoarthritis. ACS APPL MATER INTER. 2023;XXXX(XXX):XXX-XXXRead more>>
  • Tohru Mutoh. et al. Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model. J CHEM NEUROANAT. 2023 Dec;134:102362Read more>>
  • Seung-Wan Hong. et al. The Effect of Pregabalin on Microglia Differentiation in Rat with Neuropathic pain: A Preliminary Study. INT J MED SCI. 2024; 21(7): 12651273Read more>>
  • Zhuang Cuicui. et al. Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF-B-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells. ARCH MICROBIOL. 2024 Jun;206(6):1-11Read more>>
  • Rebecca A. Stairley. et al. Anti-Ferroptotic Treatment Deteriorates Myocardial Infarction by Inhibiting Angiogenesis and Altering Immune Response. ANTIOXIDANTS-BASEL. 2024 Jul;13(7):769Read more>>
  • Vendrov Aleksandr E.. et al. Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging. FRONT IMMUNOL. 2024 Jun;15Read more>>
  • Yan Sisi. et al. CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway in intrauterine adhesion. BIOL REPROD. 2024 JulRead more>>
VALIDATION IMAGES