bs-4683R-Cy5.5

DATASHEET

Host: Rabbit

Target Protein: Caspase-8 subunit p18

Immunogen Range: 201-300/4496

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 841

Swiss Prot: Q14790

Source: KLH conjugated synthetic peptide derived from human Caspase-8 subunit p18

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Conjugation: Cy5.5

Excitation/ Emission: 675nm/694nm

Size: 100ul

Concentration: 1ug/ul

Applications: FCM(1:20-100)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 18/55kDa

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.