DATASHEET
Host:
Rabbit
Target Protein:
IGF 1
Immunogen Range:
108-195/195
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
3479
Swiss Prot:
P05019
Source:
KLH conjugated synthetic peptide derived from human IGF I
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
PRODUCT SPECIFIC PUBLICATIONS
- Pian Gong. et al. The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury. Brain Res Bull. 2021 OcRead more>>
- Yamada A.K.. et al. Beta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway. Braz J Med Biol Res. 2022 Jan;55Read more>>
- Yang-Li Ye. et al. GLP-2 Ameliorates D-galactose Induced Muscle Aging by IGF-1/Pi3k/Akt/FoxO3a Signaling Pathway in C2C12 Cells and Mice. ARCH GERONTOL GERIAT. 2024 Apr;:105462Read more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded human placenta labeled with Anti-IGF I Polyclonal Antibody, Unconjugated (bs-4588R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Lane 1: IGF1 Recombinat Protein lysates; Lane 2: Contro(-) lysates probed with IGF 1 Polyclonal Antibody, Unconjugated (bs-4588R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C