bs-4539R-HRP [Conjugated Primary Antibody]
IL-6 Polyclonal Antibody, HRP Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IL-6

Immunogen Range: 110-185/212


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3569

Swiss Prot: P05231

Source: KLH conjugated synthetic peptide derived from human IL-6

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)

Predicted Molecular Weight: 23


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xiong, Weiwei, et al. "Aqueous Synthesis of Color-tunable CuInS2/ZnS Nanocrystals for Detection of Human interleukin-6." ACS Applied Materials & Interfaces (2013).Read more>>
  • Ding,et al.ZEB2 Attenuates LPS-Induced Inflammation by the NF-κB Pathway in HK-2 Cells.(2018) Inflammation. 41:722-731.Read more>>
  • Wang Y et al. Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT‐3 signalling pathway. Cell Prolif. 2019 Jun 21:e12650. Read more>>
  • Meng H et al. Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis. Eur J Pharmacol. 2019 Nov 5;862:172642. Read more>>
  • Yan Zhang. et al. Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brainCliver axis in rats. 2021 May 18Read more>>
  • Jaclyn Iannucci. et al. Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro. Curr Issues Mol Biol. 2021 Jun;43(1):215-225Read more>>
  • Leiming Sun. et al. Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats. Bioengineered. 2021;12(2):11188-112Read more>>
  • Xin Fan. et al. Anti-Colon Cancer Activity of Novel Peptides Isolated from In Vitro Digestion of Quinoa Protein in Caco-2 Cells. Foods. 2022 Jan;11(2):194Read more>>
  • Ye Tian. et al. The Mitigatory Effect of Shen-Qi Compound on the Diabetic Thoracic Aortic Complications through Inhibiting the Inflammatory Microenvironment by miR-223-3p/RBP-J/IRF8 Axis. EVID-BASED COMPL ALT. 2022 Sep 28;2022:6686931Read more>>
  • endong Yang. et al. Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-B Signaling Pathway. J AGR FOOD CHEM. 2022;XXXX(XXX):XXX-XXXRead more>>
  • De-Qi Yan. et al. Establishment of a chronic insomnia rat model of sleep fragmentation using unstable platforms surrounded by water. EXP THER MED. 2023 May;25(5):1-12Read more>>
  • Nur Setiawan Suroto. et al. Biocompatibility evaluation of electrospun Poly-L lactic Acid-chitosan immobilized with heparin as scaffold for vascular tissue repair. J SCI-ADV MATER DEV. 2023 Sep;8:100594Read more>>
  • Hai-bo Liu. et al. Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models. DRUG DES DEV THER. 2023 Aug 01Read more>>
  • Kar Ezgi. et al. Prophylactic and Therapeutic Efficacy of Boric Acid on Lipopolysaccharide-Induced Liver and Kidney Inflammation in Rats. BIOL TRACE ELEM RES. 2023 Nov;:1-13Read more>>
  • Agata Wroska. et al. High-Dose Fenofibrate Stimulates Multiple Cellular Stress Pathways in the Kidney of Old Rats. INT J MOL SCI. 2024 Jan;25(5):3038Read more>>
  • Fuyi Luo. et al. Simultaneous blastic plasmacytoid dendritic cell neoplasm and myelofibrosis: A case report. ONCOL LETT. 2024 May;27(5):1-14Read more>>
  • Linxu Wu. et al. Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence. LIFE SCI. 2024 Jul;348:122701Read more>>
  • Lubin Zhou. et al. Electrospun Self-Pumping dressing with gastrodin for immunomodulation and rapid healing of diabetic wounds. CHEM ENG J. 2024 Sep;495:153424Read more>>
  • Hseyin zkan. et al. Expression patterns of inflammatory and oxidative stress-related genes in the uterine and ovarian tissues of dogs diagnosed with pyometra based on cervical patency status. THERIOGENOLOGY. 2024 Oct;228:1Read more>>
  • Xi-Kun Yuan. et al. Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys. PHYSIOL RES. 2024 Aug 31;73(4):577-591Read more>>
VALIDATION IMAGES