bs-4310R [Primary Antibody]
VE Cadherin Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: VE Cadherin

Immunogen Range: 251-320/784


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1003

Swiss Prot: P33151

Source: KLH conjugated synthetic peptide derived from human VE Cadherin

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Size: 100ul

Concentration: 1ug/ul

Applications: FCM(1:20-100)
IHC-P(1:200-400)

Predicted Molecular Weight: 81


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Cow
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhai L et al. Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes. Stem Cell Res Ther. 2020 Jan 3;11(1):10.Read more>>
  • Hayashi T et al. Characteristics of Leiomyosarcoma: Induction of Hematogenous Metastasis by Isolated Uterine Mesenchymal Tumor Stem-like Cells Anticancer Res. 2020 Mar;40(3):1255-1265.Read more>>
  • Zhai L et al. Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes. Stem Cell Res Ther. 2020 Jan 3;11(1):10.Read more>>
  • Xia Dai. et al. Effect of Aerobic and Resistance Training on Endothelial Progenitor Cells in Mice with Type 2 Diabetes. Cell Reprogram. 2020 Aug;22(4):189-197Read more>>
  • Fenlong Xue. et al. Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet. 2021 May 3Read more>>
  • Xing Pei. et al. Cardiac-derived stem cell engineered with constitutively active HIF-1 gene enhances blood perfusion of hindlimb ischemia. J Ind Eng Chem. 2021 SepRead more>>
  • Yang Liu. et al. Octreotide modified liposomes that co-deliver paclitaxel and neferine effectively inhibit ovarian cancer metastasis by specifically binding to the SSTR2 receptors. J DRUG DELIV SCI TEC. 2024 Sep;98:105851Read more>>
VALIDATION IMAGES

Mouse kidney cells probed with VE Cadherin Polyclonal Antibody, Unconjugated (bs-4310R) at 3ug for 30 minutes followed by incubation with a FITC conjugated secondary (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).