Host: Rabbit
Target Protein: OST-beta
Immunogen Range: 57-128/128
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 123264
Swiss Prot: Q86UW2
Source: Recombinant human OST-beta protein
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Conjugation: Cy5.5
Excitation/ Emission: 675nm/694nm
Size: 100ul
Concentration: 1ug/ul
Applications: WB()
Predicted Molecular Weight: 14
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.