DATASHEET
Host:
Rabbit
Target Protein:
PER2/Period circadian protein 2
Immunogen Range:
751-850/1225
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
8864
Swiss Prot:
O15055
Source:
KLH conjugated synthetic peptide derived from human PER2
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
PRODUCT SPECIFIC PUBLICATIONS
- Mishra, Rakesh. et al. Reversible dysregulation of renal circadian rhythm in lupus nephritis. Mol Med. 2021 Dec;27(1):1-12Read more>>
- Yi-Ting Chen. et al. Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging. ANALYST. 2022 DecRead more>>
VALIDATION IMAGES
Formalin-fixed and paraffin embedded rat skin tissue labeled with Anti-PER2/Period circadian protein 2 Polyclonal Antibody, Unconjugated (bs-3927R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Formalin-fixed and paraffin embedded rat heart tissue labeled with Anti-PER2/Period circadian protein 2 Polyclonal Antibody, Unconjugated (bs-3927R) at 1:200 followed by conjugation to the secondary antibody and DAB staining