DATASHEET
Host:
Rabbit
Target Protein:
HSD11B1/HSD1
Immunogen Range:
201-292/292
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
3290
Swiss Prot:
P28845
Source:
KLH conjugated synthetic peptide derived from human HSD11B1
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Background:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
PRODUCT SPECIFIC PUBLICATIONS
- Nakata, Takaya, et al. "The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats." BMC Oral Health16.1 (2016): 108.Read more>>
- Xu et al. Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator. (2014) Fertil.Steri. 102:282-290.e4Read more>>
- Tianxin Zhao. et al. Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders. J Hazard Mater. 2022 Feb;424:127547Read more>>
VALIDATION IMAGES
This image was kindly submitted by Dragos Scarlet DVM, MSc from the University of Vienna as part of the Bioss Discovery Progarm.\n\nParaffin embedded horse duodenum labeled with Anti-11ßHSD1 Polyclonal Antibody, Unconjugated (bs-3904R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
This image was kindly submitted by Dragos Scarlet DVM, MSc from the University of Vienna as part of the Bioss Discovery Progarm.\n\nParaffin embedded horse kidney labeled with Anti-11ßHSD1 Polyclonal Antibody, Unconjugated (bs-3904R) at 1:200 followed by conjugation to the secondary antibody and DAB staining