bs-3724R [Primary Antibody]
mu Opioid Receptor (Ser375) Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: mu Opioid Receptor Ser375

Modification Site: Ser375

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 25601

Swiss Prot: P33535

Source: KLH conjugated synthetic phosphopeptide derived from rat mu Opioid Receptor around the phosphorylation site of Ser375

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 44


Predicted Cross Reactive Species: Human
Mouse
Rat
Dog
Cow
Pig
Horse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Brewer, Kori L., et al. "Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord." Frontiers in Neural Circuits 8 (2014): 62.Read more>>
  • Laureano, D. P., et al. "Intrauterine growth restriction modifies the hedonic response to sweet taste in newborn pups-role of the accumbal μ-opioid receptors." Neuroscience (2016).Read more>>
  • Sanna MD et al. μ Opioid Receptor-Triggered Notch-1 Activation Contributes to Morphine Tolerance: Role of Neuron–Glia Communication. Mol Neurobiol. 2019 Jul 25. Read more>>
VALIDATION IMAGES

Image kindly provided by Dr. Stefen Clemens of East Carolina University. pMOR protein expression levels in the spinal cords of WT and D3KO mice (top lanes), and their respective ß-actin protein expression (bottom panels). Rabbit Anti-mu Opioid Receptor (Ser375) Polyclonal Antibody was used at a dilution of 1:1000.