DATASHEET
Host:
Rabbit
Target Protein:
FPRL1/Lipoxin A4 receptor
Immunogen Range:
51-150/351
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
2358
Swiss Prot:
P25090
Source:
KLH conjugated synthetic peptide derived from human FPRL1
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
PRODUCT SPECIFIC PUBLICATIONS
- Diao, Na, et al. "Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis."Scientific Reports 6 (2016): 34672.Read more>>
- Wang et al. Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells. (2016) Sci.Re. 6:25946Read more>>
- Hebeda CB et al. Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. Cells. 2020 May 11;9(5):1188.Read more>>
- Wenzheng Xia. et al. ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway. Faseb J. 2020 Oct;34(10):13993-14005Read more>>
- Cao Yirui. et al. Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemiaCreperfusion injury. CELL MOL BIOL LETT. 2023 Dec;28(1):1-24Read more>>
- Yang Fan. et al. Identifying oxidative stress-related biomarkers in idiopathic pulmonary fibrosis in the context of predictive, preventive, and personalized medicine using integrative omics approaches and machine-learning strategies. EPMA Journal. 2023 Jul;:1-26Read more>>
- Hiram Roddy. et al. An inflammation resolution-promoting intervention prevents atrial fibrillation due to left-ventricular dysfunction. CARDIOVASC RES. 2023 DecRead more>>
VALIDATION IMAGES
Mouse cells(black) were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with FPRL1 Polyclonal Antibody(bs-3654R-FITC)at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).
Mouse spleen cells(black) were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with FPRL1 Polyclonal Antibody(bs-3511R-FITC)at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).