bs-3623R [Primary Antibody]
mu Opioid receptor Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: mu Opioid receptor

Immunogen Range: 165-270/400


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4988

Swiss Prot: P35372

Source: KLH conjugated synthetic peptide derived from human mu Opioid receptor

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 45


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Rabbit
GuineaPig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Laureano, D. P., et al. "Intrauterine growth restriction modifies the hedonic response to sweet taste in newborn pups-role of the accumbal μ-opioid receptors." Neuroscience (2016).Read more>>
  • Wu, Jian, Peng Li, and Xiuying Wu. "The effect of chronic intermittent hypoxia on respiratory sensitivity to morphine in rats." Sleep and Breathing (2017): 1-7.Read more>>
  • Hui Gao. et al. -Opioid ReceptorCMediated Enteric Glial Activation Is Involved in Morphine-Induced Constipation. 2021 Feb 23Read more>>
  • Xiaofan Xiong. et al. Cell apoptosis in the testis of male rats is elevated by intervention with -endorphin and the mu opioid receptor. REPROD BIOL. 2023 Sep;23:100789Read more>>
  • Chiu-Yi Ho. et al. Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats. EUR J PHARMACOL. 2023 Nov;:176171Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse hindfoot tumor labeled with Anti-µ-Opioid receptor Polyclonal Antibody, Unconjugated (bs-3623R) followed by conjugation to the secondary antibody and DAB staining


Formalin-fixed and paraffin embedded mouse skin labeled with Anti-µ-Opioid receptor Polyclonal Antibody, Unconjugated (bs-3623R) followed by conjugation to the secondary antibody and DAB staining


Paraformaldehyde-fixed, paraffin embedded (human cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (mu Opioid receptor) Polyclonal Antibody, Unconjugated (bs-3623R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.