bs-3429R-Cy7 [Conjugated Primary Antibody]
STAT3 (Ser727) Polyclonal Antibody, Cy7 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: STAT3 Ser727

Modification Site: Ser727

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6774

Swiss Prot: P40763

Source: KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Ser727

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 88


Cross Reactive Species: Human
Rat
Rabbit

Predicted Cross Reactive Species: Mouse
Dog
Cow
Sheep
Pig
Chicken
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Song, Yan‑Yan, et al. "STAT3, p‑STAT3 and HIF‑1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma."Oncology letters 8.1 (2014): 431-437.Read more>>
  • Gao, Ling, et al. "Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition." Drug Design, Development and Therapy 11 (2017): 1789.Read more>>
  • Xu et al. Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways. (2018) Exp.Anim. 67:127-137Read more>>
  • Lei Yuet al. TMF, a natural dihydroflavonoid isolated from Scutellaria javanica Jungh, stimulates anticancer activity of s180 cancer-bearing mice, induces apoptosis, inhibits invasion and migration on HepG-2?cells. J Ethnopharmacol. 2020 Dec 5;263:113072.Read more>>
  • Dong Wang. et al. Antifibrotic effect of Gancao Ganjiang decoction is mediated by PD-1 / TGF-1 / IL-17A pathway in bleomycin-induced idiopathic pulmonary fibrosis. J Ethnopharmacol. 2021 Dec;281:114522Read more>>
  • Xiaowei Qin. et al. Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells. J CELL PHYSIOL. 2022 May 16Read more>>
  • Xueyang Chen. et al. A20 Enhances the Expression of the Proto-Oncogene C-Myc by Downregulating TRAF6 Ubiquitination after ALV-A Infection. VIRUSES-BASEL. 2022 Oct;14(10):221Read more>>
VALIDATION IMAGES